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E towards the cell [74]. When inside, the very first step in glycolysis would be the irreversible conversion of glucose to glucose 6-phosphate, catalyzed by hexokinases (HKs) I-IV [63, 75, 76]. Particularly, HK-II will be the predominant isoform in insulin-sensitive tissues [76] and can be upregulated as much as 100-fold in cancer [75]. Furthermore, HK-II competitively binds to the voltage-depende

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